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Hormones from the adrenal and gonadal sytems are eliminated through the urine or bile in the liver.
Unbound steroid hormones from the gonadal and adrenal glands are transformed in the liver, where they become inactive, and subsequently eliminated through the bile or urine. The lungs, cell metabolites, or feces do not contain adrenal or gonadal steroid hormones. The steroid hormones are broken down by several tissues, but mostly the liver, into physiologically inactive byproducts that are primarily excreted in the urine, although some are also removed via the bile and, finally, the feces. Analysis of urine steroids may aid in the diagnosis of endocrine disorders. The liver is the primary site of steroid metabolism. Tetrahydro derivatives are created in the first step by reducing double bonds and adding hydroxyl to the ring.
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