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Mismatched ABO blood groups and Rh antigens can both lead to serious transfusion reactions.
Transfusion reactions can indeed result from mismatched ABO blood groups due to hemolytic transfusion reactions (HTR). However, mismatched Rh antigens can also cause similar reactions as they lead to the production of anti-Rh factor antibodies that can trigger a delayed or rapid HTR upon subsequent transfusions.
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